Submitted to: Journal of Food Lipids
Publication Type: Review Article
Publication Acceptance Date: 5/29/2011
Publication Date: 7/24/2011
Citation: Dodson, M.V., Mir, P.S., Hausman, G.J., Guan, L.L., Du, M., Jiang, Z., Fernyhough, M.E., Bergen, W.G. 2011. Obesity, metabolic syndrome and adipocytes. Journal of Food Lipids. 721686. Interpretive Summary: Many human diseases arise from the condition of obesity or excess fatnesss. Excess fatness is physically obvious in just several parts of the body but it is manifested in many parts of the body. In the treatment of obesity or excess fatness all the locations or sites of fat accumulation must be studied for involvement in diseases related to adiposity.
Technical Abstract: Obesity and metabolic syndrome are examples whereby excess energy consumption and energy flux disruptions are causative agents of increased fatness. Because other, as yet elucidated, cellular factors may be involved and because potential treatments of these metabolic problems involve systemic agents that are not adipose depot-specific in their actions, should we be thinking of adipose depot-specific (cellular) treatments for these problems? For sure, whether treating obesity or metabolic syndrome, the characteristics of all adipose depot-specific adipocytes and stromal vascular cells should be considered.