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United States Department of Agriculture

Agricultural Research Service

Research Project: NEWCASTLE DISEASE EPIDEMIOLOGY, PATHOGENESIS, AND CONTROL

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Title: The effect of IL-2 expression by recombinant Newcastle disease virus on host immune response, viral replication and pathogenesis)

Author
item Edwards, Ingrid
item Susta, Leonardo
item Cardenas, Stivalis
item Miller, Patti
item Brown, Corrie
item Afonso, Claudio

Submitted to: Meeting Abstract
Publication Type: Abstract only
Publication Acceptance Date: 3/15/2011
Publication Date: 5/15/2011
Citation: Edwards, I.C., Susta, L., Cardenas, S., Miller, P.J., Brown, C.C., Afonso, C.L. 2011. The effect of IL-2 expression by recombinant Newcastle disease virus on host immune response, viral replication and pathogenesis [abstract]. 1st International Avian Respiratory Disease Conference, May 15-18, 2011, Athens, Georgia. p. 34.

Interpretive Summary:

Technical Abstract: Interleukin 2 (IL-2) is a soluble cytokine that stimulates the cell-mediated immune response. Virus constructs, such as recombinant vaccinia virus, expressing chicken IL-2 have been shown to improve viral clearance by natural killer cells in mice. We have inserted the open-reading frame of the chicken IL-2 gene into a viscerotropic velogenic Newcastle disease virus backbone (recombinant ZJ1 strain) in order to determine how the expression of IL-2 at the site of infection during viral replication affects the local and systemic immune response, viral replication and viral pathogenesis. Results from embryo inoculation (mean death time), intra-cranial pathogenecity index, cell culture multistep growth curve and chicken pathogenesis experiments will be presented.

Last Modified: 8/24/2016
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