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United States Department of Agriculture

Agricultural Research Service

Research Project: ABSORPTION AND METABOLISM OF ESSENTIAL MINERAL NUTRIENTS IN CHILDREN

Location: Children's Nutrition Research Center

Title: Variations in cord 25-hydroxyvitamin D levels in Hispanic and Caucasian infants are not related to neonatal bone mineral status)

Author
item Hicks, Penni
item Hawthorne, Keli
item Rogers, Stefanie
item Carpenter, Thomas
item Abrams, Steven

Submitted to: Journal of Federation of American Societies for Experimental Biology
Publication Type: Abstract Only
Publication Acceptance Date: 1/20/2010
Publication Date: 4/26/2010
Citation: Hicks, P.D., Hawthorne, K.M., Rogers, S.P., Carpenter, T.O., Abrams, S.A. 2010. Variations in cord 25-hydroxyvitamin D levels in Hispanic and Caucasian infants are not related to neonatal bone mineral status [abstract]. Journal of Federation of American Societies for Experimental Biology. 24:325.4.

Interpretive Summary:

Technical Abstract: At birth, an infant’s vitamin D status, as assessed by 25-hydroxyvitamin D level (25-OHD), is dependent on the 25-OHD status of the mother. There are few data regarding 25-OHD in Hispanic infants and the relationship between 25-OHD and bone mineral outcomes. To evaluate the range of 25-OHD in Hispanic newborn infants (HNI) compared to Caucasian newborn infants (CNI) in a southern US setting and to determine if cord blood 25-OHD is related to bone mineral status in the first week of life. At birth, umbilical cord blood was analyzed using the Diasorin RIA (Diasorin Inc, Stillwater, MN) for 25-OHD. Approximately 1 week after birth, infants’ received a whole body dual-energy x-ray absorptiometry measurement to assess bone mineral content/density (BMC/BMD). Data are Mean +/- SD. The 25-OHD levels were significantly lower in HNI (n=20) versus CNI (n=18) (17.2 +/- 5.7 ng/mL vs 24.1 +/- 6.8 ng/mL, p = 0.002). There was no difference in whole body BMC or BMD between HNI and CNI (BMD: 0.197 +/- 0.013 g/cm2 vs 0.196 +/- 0.011 g/cm2, p = 0.9). Using a value of 20 ng/mL to indicate possible vitamin D insufficiency there was no difference in BMC or BMD of 19 infants with 25-OHD levels < 20 ng/mL vs 19 infants with 25-OHD levels 20 ng/mL (BMD: 0.195 +/- 0.015 g/cm2 vs 0.197 +/- 0.011 g/cm2, p = 0.8). Hispanic newborns in a southern US setting have lower 25-OHD than Caucasians, but this is not related to newborn bone mineral status.

Last Modified: 8/24/2016
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