|LING, ZHAO - University Of Tennessee|
|LEE, JOO YOUNG - Gwangju Institute Of Science And Technology|
Submitted to: Nutrition Reviews
Publication Type: Review Article
Publication Acceptance Date: 5/30/2011
Publication Date: 6/1/2011
Citation: Ling, Z., Lee, J., Hwang, D.H. 2011. Inhibition of pattern recognition receptor-mediated inflammation by bioactive phytochemicals. Nutrition Reviews. 69:6(310-320).
Interpretive Summary: It is now well recognized that pattern recognition receptor (PRR)-mediated inflammation leads to the development and progression of many chronic diseases including insulin resistance. Recent studies by researchers' at the Western Human Nutrition Research Center in Davis, California revealed that PRR-mediated inflammation can be inhibited by certain bioactive phytochemicals. The far reaching implication of these results is that risk of insulin resistance and other chronic diseases can be reduced by such phytochemicals in our diet. This review summarizes these results which are obtained almost entirely from the USDA/ARS Lab.
Technical Abstract: Emerging evidence reveals that pattern-recognition receptors (PRRs), Toll-like receptors (TLRs) and Nucleotide-binding oligomerization domain proteins (NODs) mediate both infection-induced and sterile inflammation by recognizing pathogen-associated molecular patterns (PAMPs) and endogenous molecules, respectively. PRR-mediated chronic inflammation is an important determinant for the development and progression of chronic diseases including cancer and insulin resistance. Recent studies demonstrated that certain bioactive phytochemicals inhibit agonist-induced activation of PRRs. These results suggest that PRRs and their downstream signaling components are important molecular targets for dietary strategies to reduce PRR-mediated chronic inflammation and consequent risks of chronic diseases.