Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 6/1/2010
Publication Date: 7/11/2010
Citation: Chen,, S., Lu, S., Yu, H., Mitchum, M., Wang, X. 2010. Diverse CLE peptides from cyst nematode species. Meeting Abstract. p. 20. Interpretive Summary:
Technical Abstract: Plant CLAVATA3/ESR (CLE)-like peptides play diverse roles in plant growth and development including maintenance of the stem cell population in the root meristem. Small secreted peptides sharing similarity to plant CLE signaling peptides have been isolated from several cyst nematode species including soybean cyst nematode (Heterodera glycines), sugarbeet cyst nematode (H. schachtii), potato cyst nematodes (Globodera rostochiensis and G. pallida), and tobacco cyst nematode (G. tabacum). Interestingly, unlike typical plant and Heterodera CLEs that contain a single C-terminal CLE motif, most of the Globodera CLE genes encode CLE proteins with multiple CLE motifs. H. glycines CLEs have recently been demonstrated to be secreted into nematode-induced feeding cells. Moreover, our in-depth functional characterization demonstrated a functional similarity of nematode CLEs to endogenous plant CLE peptides, suggesting that once nematode CLEs are delivered into plant cells, they can exert their function as endogenous plant CLEs to redirect plant CLE signaling pathways to establish a successful parasitic association with host plants. The wide distribution of CLEs in cyst nematode species indicates that ligand mimicry of plant CLEs is an important mechanism in cyst nematode parasitism of host plants. A better understanding of this extraordinary example of molecular mimicry will advance our knowledge of plant-nematode interactions.