Location: Children's Nutrition Research CenterTitle: Argininosuccinate lyase is an essential regulator of nictric oxide homeostatis Author
Submitted to: Molecular Genetics and Metabolism
Publication Type: Abstract Only
Publication Acceptance Date: 3/1/2009
Publication Date: 11/3/2009
Citation: Erez, A., Chen, Y., Shchelochkov, O.A., Nagamani, S.S., Mian, A., Bertin, T.K., Jiang, M., Black, J.0., Garg, H., Zeng, H., Summar, M., O'Brien, W.E., Mitch, W.E., Aschner, J.L., Marini, J.C., Bryan, N.S., Lee, B. 2009. Argininosuccinate lyase is an essential regulator of nictric oxide homeostatis [abstract]. Molecular Genetics and Metabolism. 98:142. Interpretive Summary:
Technical Abstract: The regulation of nitric oxide synthesis is a complex mechanism, depending on the availability of substrates and the activity of the enzymes involved. Here we describe in a mouse model the channeling of urea cycle intermediates for the recycling of citrulline and the transport of extracellular arginine to sustain an arginine intracellular pool utilized for nitric oxide synthesis.