|Koch, Stephen - State University Of New York (SUNY)|
Submitted to: Inorganic Biochemistry
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 7/3/2007
Publication Date: 7/16/2007
Citation: Chang, S., Koch, S.A. 2007. [FeIII(SR)4]1- Complexes can be Synthesized by the Direct Reaction of Thiolates with FeCl3. Journal of Inorganic Biochemistry. 101(11-12:1758-1759.
Interpretive Summary: The research focused to synthesized and fully characterized new types of metal-thiolate complexes for the purpose of obtaining fundamental information about the structural, spectroscopic and reactivity properties of proteins containing metal-cysteine interactions. The metal-cysteine ligation mode occurs in a wide range of metalloproteins that are of vast biological and medical significances. Results obtained in this paper have demonstrated that sterically encumbered thiolates react with iron(III) to form monomeric species and to stabilized iron(III) in high oxidation states using new developed methods. Chemico-physical studies of these model compounds will be used to achieve a fundamental understanding of the relationship between the spectroscopic and the structural and electronic properties of the metal center.
Technical Abstract: It is shown that the previously characterized [FeIII(SR)4]1- (R=Et, i-Pr, Ph) complexes can be synthesized by the direct reaction of 4 equivalents of LiSR with FeCl3 in DMF solution. [FeIII(SR)4]1- complexes are synthetic analogs for the [FeIII(S-Cystein)4] center in rubredoxin proteins.