Submitted to: Biochemical and Biophysical Research Communications
Publication Type: Review Article
Publication Acceptance Date: 3/1/2010
Publication Date: 4/3/2010
Citation: Dodson, M.V., Vierck, J.L., Hausman, G.J., Guan, L.L., Fernyhough, M.E., Poulos, P.S., Mir, P.S., Jiang, Z. 2010. Examination of adipose depot-specific PRAR moieties. Biochemical and Biophysical Research Communications. 394 (issue 2). p.241-242. Interpretive Summary: Mechanisms of fat cell formation activation are being defined rapidly as demonstrated by the large number of published studies. The many differences between fat cell depots in laboratory animals is precipitating similar research in meat animals. The size of fat cell depots in meat animals makes it relatively easy to study mechanisms of fat cell formation. Examination of meat-animal depot-specific fat cell inducers may provide new information about fat cell regulation that is relative to humans and all animals.
Technical Abstract: Molecular mechanisms of peroxisome proliferator activated receptors (PPARs) are being defined rapidly, as illustrated by the volume of papers published. Much of the research is directed towards a clinical end-point/application; however, the non-homogeneous nature of adipose depots in laboratory animals is spurring similar research in domestic meat animals (such as beef cattle). Moreover, the size of adipose depots in meat animals remains an attractive feature for using them to obtain cells for PPAR research. Examination of meat-animal depot-specific PPAR moieties may provide novel information about adipocyte regulation that might be extrapolated to all animals.