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United States Department of Agriculture

Agricultural Research Service


Location: Livestock Issues Research

Title: Influence of two different doses of infectious bovine rhinotracheitis virus (IBRV) on immune and physiological parameters in steers

item Falkenberg, Shollie
item Schmidt, Ty
item Elsasser, Theodore
item Sartin, Jim
item Buntyn, Joe
item Carroll, Jeffery - Jeff Carroll

Submitted to: Journal of Animal Science Supplement
Publication Type: Abstract Only
Publication Acceptance Date: 7/11/2010
Publication Date: 10/11/2010
Citation: Falkenberg, S., Schmidt, T., Elsasser, T.H., Sartin, J., Buntyn, J., Carroll, J.A. 2010. Influence of two different doses of infectious bovine rhinotracheitis virus (IBRV) on immune and physiological parameters in steers [abstract]. 2010 American Society of Animal Science Meeting, July 11-15, 2010, Denver, CO. Journal of Animal Science. 88(E-Supplement 2):T21.

Interpretive Summary:

Technical Abstract: To evaluate the effects different doses of IBRV and the impact they have on immunological and physiological parameters of cattle, 18 Holstein steers (450.11 ± 75.70 kg) were randomly assigned to either a control group or 1 of 2 IBRV challenged groups. Prior to the challenge, steers were fitted with an indwelling rectal probe, BW were recorded, and a blood sample was obtained. On d 0, steers received either an intra-nasal dose of IBRV [3 ml/nostril (Group 1) or 4ml/nostril (Group 2); Cooper strain, 1 X 10 exp 6-7 PFU] or saline (3 ml/nostril; Control). IBRV exposed steers were placed in a paddock that was isolated from the Control cattle as well as all other cattle located on the research farm. Blood samples were collected via jugular venipuncture every 24 h on d 1 and 2, and every 12 h on d 3, 4, 5, 6, and 7 post-challenge. All IBRV steers had elevated rectal temperatures (p < 0.05) as compared to Control steers by d 2, returning to baseline on approximately d 5. Serum was analyzed for interleukin-6 (IL-6), interferon-gamma (IFN), tumor necrosis factor-alpha (TNF), growth hormone (GH) and insulin-like growth factor-1 (IGF-1). A difference (p <0.05) was observed in IFN, there was an increase in IFN for the IBRV challenged steers as compared to the Control cattle. No differences (p > 0.05) were observed for the other parameters of interest; TNF, IL-6, GH and IGF-1 between Control and IBRV challenged steers. We observed an increase in TNF and IL-6, however there were no differences (p > 0.05) in these concentrations as compared to the Control steers. There was a difference between the Control and IBRV steers for IFN, but no differences were observed between the 2 IBRV groups for parameters of interest. The results indicate that both doses elicited an immune response, however there was no differences in the 2 doses. It is plausible that the minimal differences observed in the parameters of interest could be a result of the sampling intervals.

Last Modified: 10/19/2017
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