Submitted to: Nutrition Reviews
Publication Type: Review Article
Publication Acceptance Date: 12/21/2009
Publication Date: 3/1/2010
Citation: Booth, S.L. 2010. Dietary vitamin K guidance: an effective strategy for stable control of oral anticoagulation?. Nutrition Reviews. 68(3):178–181. Interpretive Summary:
Technical Abstract: Numerous factors have been identified as risk factors for instability of oral anticoagulation, including variability in vitamin K intake. However few studies have directly tested the feasibility of manipulating dietary vitamin K to achieve stable oral anticoagulation. Recent findings from a randomized clinical trial suggest that dietary vitamin K manipulation is a viable option for managing stability of oral anticoagulant therapy. The approach appears to be effective for those patients who are under-anticoagulated, and consume a small number of vitamin K-rich food sources. While an encouraging option for management of warfarin therapy, longer-term studies in different patient populations are required.