Location: Children's Nutrition Research CenterTitle: Bone mineral content (BMC) and serum vitamin D concentrations of infants fed partially hydrolyzed infant formulas) Author
Submitted to: Journal of Federation of American Societies for Experimental Biology
Publication Type: Abstract Only
Publication Acceptance Date: 3/1/2009
Publication Date: 4/21/2009
Citation: Litov, R.E., Groh-Wargo, S., Brabec, B.A., Zeigler, E.E., Abrams, S.A., Borschel, M.W. 2009. Bone mineral content (BMC) and serum vitamin D concentrations of infants fed partially hydrolyzed infant formulas [abstract]. Journal of Federation of American Societies for Experimental Biology. 23:731.3. Interpretive Summary:
Technical Abstract: The purpose of the study was to compare the bone status of healthy, term infants fed partially hydrolyzed whey formulas during the first 3 mo of life. Between 0 and 8 d of age, 89 infants were randomized to Good Start Supreme (GSS) or an experimental whey-based formula (EF) to 84 d of age. BMC was assessed less than or equal to 14 d and at 84 d of age. Blood biochemistries (serum Ca, P, skeletal alkaline phosphatase, parathyroid hormone and 25-OH Vit D) were assessed at 56 d of age. BMC was similar at 0-14 d. EF infants had significantly greater BMC than GSS infants at 84 d (mean +/- SEM) (117.2 +/- 4.5 g vs 110.8 +/- 4.4 g, respectively, p=0.0407). There were no differences in blood biochemistries between groups except EF infants had significantly higher serum 25-OH Vit D levels than those fed GSS (31.0 +/- 0.9 vs 27.2 +/- 0.7 ng/mL, respectively, p=0.0010, Effect Size=0.76). The average serum Vit D level in the EF group was greater than the levels of 76% of the GSS group. 97% of all infants had Vit D levels >21 ng/mL. Ca and P content of GSS (542 mg Ca/L, 315 mg P/L) was lower than that of EF (869 mg Ca/L, 556 mg P/L) and likely resulted in the BMC differences observed. Vit D intakes appeared similar as Vit D contents of 2 batches of GSS were 518 and 538 IU/L, EF was 541 IU/L. The absence of palm olein oil in EF is one possible factor that may have contributed to improved Vit D bioavailability and status.