Submitted to: Trends in Plant Science
Publication Type: Review article
Publication Acceptance Date: 9/14/2009
Publication Date: 10/8/2009
Publication URL: www.sciencedirect.com/science?_ob=MImg&_imagekey=B6TD1-4XDCKR3-3-1&_cdi=5185&_user=6956098&_pii=S1360138509002337&_orig=na&_coverDate=12%2F31%2F2009&_sk=999859987&view=c&wchp=dGLzVlb-zSkzS&md5=f0393089704beb522942bdf33e806fb5&ie=/sdarticle.pdf
Citation: Zhang, Y., Mccormick, S.M. 2009. AGCVIII Kinases: at the crossroads of cellular signaling. Trends in Plant Science. 14(12):689-695. Interpretive Summary: This review article discusses the roles that a group of proteins called AGCVIII kinases play in plant development, and outlines how calcium and phospholipids regulate these kinases.
Technical Abstract: AGCVIII kinases regulate diverse developmental and cellular processes in plants. As putative mediators of secondary messengers, AGCVIII kinases potentially integrate developmental and environmental cues into specific cellular responses through substrate phosphorylation. Here we discuss the functionality and regulation of AGCVIII kinases. Specifically, we question the view that activities of AGCVIII kinases, like their animal counterparts, are regulated by a common regulator, 3-phosphoinositide-dependent protein kinase-1 (PDK1). Instead, increasing evidence suggests that Ca2+ and phospholipids regulate AGCVIII kinases, by altering their activities or by affecting their subcellular localization. As AGCVIII kinases are at the crossroads of plant cellular signaling, they and the signaling networks in which they participate are keys to a better understanding of plant development and of interactions with their environment.