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Location: Nutrient Data Laboratory

Title: Levels of the Antioxidant Nutrients Vitamin C, Vitamin E, and Selenium in the Dietary Supplement Ingredient Database: NHANES Data Applications

item Zhao, Cuiwei
item Roseland, Janet
item Andrews, Karen
item Feinberg, Matthew
item Middleton, Augela
item Holden, Joanne
item Douglass, Larry
item Dwyer, Joanna
item Picciano, Mary Frances

Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 9/25/2009
Publication Date: 11/5/2009
Citation: Zhao, C., Roseland, J., Andrews, K.W., Feinberg, M., Middleton, A., Holden, J.M., Douglass, L.W., Dwyer, J.T., Picciano, M. 2009. Levels of the antioxidant nutrients vitamin C, vitamin E, and selenium in the dietary supplement ingredient database: NHANES data applications. American Institute for Cancer Research, November 5-6, 2009, Washington, DC.

Interpretive Summary:

Technical Abstract: Laboratory evidence indicates that antioxidants may slow or possibly prevent the development of certain cancers by protecting cells from damage caused by free radicals or other mechanisms. Many dietary supplements containing antioxidant constituents (e.g., vitamin C) are available to consumers. The Nutrient Data Laboratory (NDL), Beltsville Human Nutrition Research Center (BHNRC), part of the USDA Agricultural Research Service, working with the Office of Dietary Supplements, NIH, and other federal agencies, has developed a Dietary Supplement Ingredient Database (DSID) to estimate levels of ingredients in dietary supplement products. The first release of the DSID (DSID-1) provides data regarding predicted analytical levels for 18 nutrients in adult multivitamin/minerals (MVMs) which are linked with NHANES dietary supplement data. DSID-1 data are available at For DSID-1, multiple lots of more than 100 representative products were collected from various retail and direct sales channels then chemically analyzed for their nutrient content. The analytical values were compared to labeled values and the mean percentage differences between the two values were calculated for each nutrient. These results were analyzed by regression techniques. The derived prediction equations showed linear relationships for the antioxidant nutrients vitamin C, vitamin E, and selenium over the respective ranges studied. Prediction equations were applied to labeled nutrient levels for adult MVM products reported as consumed by respondentns in the National Health and Nutrition Examination Survey (NHANES) 2005-06. The predicted mean %-difference-from-label ranged from 7.7% to 8.5% for vitamin C, -0.12% to 6.5% for vitamin E, and 22% to 26% for selenium. DSID-1 provides researchers with data for 18 nutrients, including these antioxidant nutrients, to allow for a more accurate estimation of these constituents in diets.