Submitted to: Genbank
Publication Type: Other
Publication Acceptance Date: 6/23/2009
Publication Date: 6/23/2009
Citation: Yeh, H., Klesius, P.H. 2009. Channel catfish, Ictalurus punctatus, chemokine receptor CXCR4 cDNA. Genbank. Accession No. G2169128.
Technical Abstract: Chemokine receptor CXCR4, a member of the G protein-coupled receptor superfamily, binds selectively CXCL12. This protein plays many important roles in immunological as well as pathophysiological functions. In this communication, we identified and characterized the channel catfish CXCR4 transcript. The full-length nucleic acid sequence of channel catfish CXCR4 cDNA comprised of 1,994 nucleotides, including an open reading frame, which appears to encode a putative peptide of 357 amino acid residues with a calculated molecular mass of 40.1 kDa. By comparison with human counterpart, the channel catfish CXCR4 peptide can be divided into domains, including seven transmembrane domains, four cytoplasmic domains, and four extracellular domains. This result provides important information for further elucidating CXCR4 in channel catfish.