Page Banner

United States Department of Agriculture

Agricultural Research Service


Location: Arkansas Children's Nutrition Center

Title: Restoration of regenerative osteoblastogenesis in aged mice: Modulation of TNF

item Wahl, Elizabeth
item Aronson, James
item Liu, Lichu
item Fowlkes, John
item Thrailkill, Kathryn
item Bunn, Robert
item Skinner, Robbert
item Miller, Mike
item Cockrell, Gael
item Clark, Lindsey
item Ou, Yang
item Isales, Carlos
item Badger, Thomas
item Ronis, Martin
item Sims, John
item Lumpkin, Charles

Submitted to: Journal of Bone and Mineral Research
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 5/18/2009
Publication Date: 1/15/2010
Citation: Wahl, E.C., Aronson, J., Liu, L., Fowlkes, J.L., Thrailkill, K.M., Bunn, R.C., Skinner, R.A., Miller, M.J., Cockrell, G., Clark, L.M., Ou, Y., Isales, C.M., Badger, T.M., Ronis, M.J., Sims, J., Lumpkin, C.K. 2010. Restoration of regenerative osteoblastogenesis in aged mice: Modulation of TNF. Journal of Bone and Mineral Research. 25(1):114-123.

Interpretive Summary: The results of this study demonstrate that poorly healing fractures in elderly patients can be treated successfully with an already FDA approved drug.

Technical Abstract: Skeletal changes accompanying aging are associated with both increased risk of fractures and impaired fracture healing, which, in turn, is due to compromised bone regeneration potential. These changes are associated with increased serum levels of selected proinflammatory cytokines, e.g., tumor necrosis factor (TNF alpha). We have used a unique model of bone regeneration to demonstrate (1) that aged-related deficits in direct bone formation can be restored to young mice by treatment with TNF blockers and (2) that the cyclin-dependent kinase inhibitor p21 is a candidate for mediation of the osteoinhibitory effects of TNF. It has been hypothesized recently that TNF antagonists may represent novel anabolic agents, and we believe that the data presented here represent a successful test of this hypothesis.

Last Modified: 06/25/2017
Footer Content Back to Top of Page