Location: Arkansas Children's Nutrition CenterTitle: Early effects of dietary soy and genistein in rodent models of mammary tumorigenesis Author
Submitted to: Federation of American Societies for Experimental Biology Conference
Publication Type: Abstract Only
Publication Acceptance Date: 2/11/2009
Publication Date: 4/1/2009
Publication URL: http://www.fasebj.org.libproxy.uams.edu/content/vol23/1_MeetingAbstracts/aindex.shtml#A
Citation: Simmen, R.C., Su, Y., Pabona, J., Rahal, O., Simmons, C., Hennings, L. 2009. Early effects of dietary soy and genistein in rodent models of mammary tumorigenesis [abstract]. FASEB J. 23(1_MeetingAbstracts):897.3. Interpretive Summary:
Technical Abstract: The risk of breast cancer is highly modifiable by diet. Breast cancer may have its origins during early mammary development, thus the increasing popularity of soy food consumption among pregnant and breast-feeding women and early exposure to soy protein and bioactive components through soy infant formula could have significant implications on adult incidence of this disease. Since soy protein isolate (SPI) and genistein (GEN) diets decreased chemically induced tumor incidence in adult female rats, dietary effects on genetic pathways underlying mammary tumorigenesis were evaluated. In rat mammary epithelial cells, SPI and GEN, relative to casein diet, increased tumor suppressor PTEN and E-cadherin expression; these effects were recapitulated in vitro by GEN. Dietary SPI also decreased lipogenic gene expression in rat mammary stromal adipocytes in vivo, which was mimicked by GEN in 3T3-L1 adipocytes in vitro. Since Wnt signaling perturbation alters the epithelial hierarchy, MMTV-Wnt1 mice were investigated for dietary SPI and GEN effects on mammary progenitor cell population during disease development. Female mice at weaning were assigned to CAS, SPI-, or GEN-based diets and mammary tumor incidence was monitored. Diet-mediated changes in mammary transcriptional programs and in epithelial subpopulations may underlie protection from developing mammary lesions.