Virus Competition for Shedding and Tumor Formation Over Time in Marek's Disease Virus Dual-infected Chickens

Authors: Dunn, John; Witter, Richard; Silva, Robert; Lee, Lucy; FITZGERALD, SCOTT - Michigan State University; KANEENE, JOHN - Michigan State University; FULTON, RICHARD - Michigan State University

Submitted to: American Veterinary Medical Association Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 7/11/2009
Publication Date: 7/11/2009
Citation: Dunn, J.R., Witter, R.L., Silva, R.F., Lee, L.F., Fitzgerald, S.D., Kaneene, J.B., Fulton, R.M. 2009. Virus Competition for Shedding and Tumor Formation Over Time in Marek's Disease Virus Dual-infected Chickens [abstract]. In: 146th American Veterinary Medical Association Convention Notes, July 11-14, 2009, Seattle, Washington. Paper No. 7655.

Interpretive Summary:

Technical Abstract: This study was designed to determine what effect multiple virulent Marek’s disease viruses have on each other over time during dual-infection. Serotype 1 viruses able to be differentiated were administered either simultaneously or with a short (24 hours) or long (13 days) interval. Virus frequency and quantity was measured in tumors at termination and from feathers at three time points from 226 birds with tumors. The same virus tended to dominant at all time points, but the particular virus that dominated was more affected by time interval between challenges than by virulence. Even after the long interval, the second virus can still be important.