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Title: Extraction and determination of chondroitin sulfate from fish processing byproducts

item Stine, Jesse
item Wu, Ted
item OLIVEIRA, ALEXANDRA - University Of Alaska
item SMILEY, SCOTT - University Of Alaska
item Bechtel, Peter

Submitted to: Meeting Proceedings
Publication Type: Proceedings
Publication Acceptance Date: 1/5/2009
Publication Date: 10/20/2010
Citation: Stine, J.J., Wu, T.H., Oliveira, A.C., Smiley, S., Bechtel, P.J. 2010. Extraction and determination of chondroitin sulfate from fish processing byproducts. Meeting Proceedings. In: P.J. Bechtel and S. Smiley (eds.), A Sustainable Future: Fish Processing Byproducts. Alaska Sea Grant, University of Alaska Fairbanks, pp. 41-53. doi: 10.4027/sffpb.2010.04.

Interpretive Summary:

Technical Abstract: Chondroitin sulfate (CS) refers to a group of sulfated glycosaminoglycan containing a chain of alternating N-acetylgalactosamine and glucuronic acid sugars. It is a major component of the extracellular matrix of cartilage and attached to proteins. CS is usually an over the counter dietary supplement used to treat osteroarthritis. Sources of CS included cartilaginous tissues from cow trachea, pig ears and snouts, shark and salmon. There is a large quantity of cartilage material produced as byproduct from fisheries in Alaska and elsewhere. As a result the byproducts provide a potential to extract useful quantities of CS from the fisheries material. This study is conducted to determine the concentrations of chondroitin sulfate extractable from fish byproducts in Alaska. Samples of various byproducts prepared by our labs were sent to a commercial laboratory for CS analysis. Results indicated that chum salmon heads and whitefish stickwater fractions contained the largest quantities of CS. Low levels of approximately 1% on a dry weight bases were found in pollock byproducts. Analytical techniques developed in our laboratory for detection the extraction and of CS are being used to determine levels in a broader range of byproducts. This study indicates that certain fisheries byproducts could provide a readily available source of CS.