|ANDERSON, WILLIAM - Dow Chemical Company|
|Yokoyama, Wallace - Wally|
Submitted to: Journal of Diabetes
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 7/1/2009
Publication Date: 9/1/2009
Citation: Hung, S., Bartley, G.E., Young, S.A., Albers, D., Dielman, D., Anderson, W.H., Yokoyama, W.H. 2009. Dietary Fiber Improves Lipid Homeostatis and Modulates Adipocytokines in Hamsters. Journal of Diabetes. 1:1-13.
Interpretive Summary: Americans are the most obese population in the world. The concern from a public health perspective is that obesity is accompanied by chronic diseases such as cardiovascular disease and diabetes. Adipocytes (fat cells) produce signaling agents including leptin and adiponectin. Leptin reduces fat accumulation in humans and animals that are leptin deficient. Leptin is usually higher in obese individuals due to leptin resistance. Adiponectin is believed to reduce atherogenicity and prevent diabetes. Adiponectin levels are elevated by soluble cellulose (hydroxypropylmethylcellulose) feeding of test animals. Plasma lipids are also reduced.
Technical Abstract: Adiponectin is a small protein secreted by fat cells that mediates lipid and glucose homeostasis. The plasma level of adiponectin has been found to be negatively correlated with other risk factors of Metabolic Syndrome. The Syrian golden hamster has been widely used as an animal model for studying lipid metabolism because of its similarity in lipoprotein profile and metabolism to humans. Despite the importance of hamster adiponectin in the energy homeostasis, it has not previously been identified. In this study, hamster adiponectin was sequenced and endogenous adiponectin from hamster plasma was purified and characterized. Hamster adiponectin is comprised of 244 amino acid residues; and the purified protein has an apparent molecular weight of 30 kDa, consistent with the adiponectin reported in other species. Hydroxypropylmethycellulose feeding increased adiponectin, and reduced plasma cholesterol and triglyceride levels. Collectively, these results suggest that adiponectin was regulated by HPMC and may play a pivotal role in the hypocholesterolemic effect.