Submitted to: Recent Patents on Food, Nutrition and Agriculture
Publication Type: Review Article
Publication Acceptance Date: 10/16/2008
Publication Date: 10/21/2008
Citation: Liu, G. 2009. Applications and Case Studies of the Next-Generation Sequencing Technologies in Food, Mutrition and Agriculture. Recent Patents on Food, Nutrition & Agriculture. 1(1):75-79. Interpretive Summary:
Technical Abstract: Next-generation sequencing technologies are able to produce high-throughput short sequence reads in a cost-effective fashion. The emergence of these technologies has not only facilitated genome sequencing but also changed the landscape of life sciences. Here I survey their major applications ranging from whole-genome sequencing and resequencing, single nucleotide polymorphism (SNP) and structural variation discovery, to mRNA and noncoding RNA profiling and ChIP-seq. These case studies in comparative and functional genomics, epigenomics, and metagenomics are providing a more complete picture of the genome structures and functions. In the near future, we will witness broad impacts of these next-generation sequencing technologies for solving complex biological problems in food, nutrition and agriculture.