|Reinhardt, Timothy - Tim|
Submitted to: American Society for Bone and Mineral Research
Publication Type: Abstract only
Publication Acceptance Date: 8/29/2008
Publication Date: 9/12/2008
Citation: Kremer, R., Campbell, P., Reinhardt, T.A., Gilsanz, V. 2008. Vitamin D status in young women is strongly negatively related to body weight, body mass index and body fat, but is not associated to bone mass [abstract]. Journal of Bone and Mineral Research. 23(abstracts supplement):S290. Interpretive Summary:
Technical Abstract: Available data in elderly adults suggest that circulating 25-hydroxyvitamin D (250HD) concentrations are positively correlated with bone mineral density (BMD) and inversely associated with obesity. To characterize whether these relations are also present at the time of peak bone mass, we examined the associations between serum 250HD measures using a radioimmunoassay and values for weight (wt) and body mass index (BMI), and bone and fat determinations obtained by dual energy x-ray absorptiometry (DXA) and computed tomography (CT) in 90 white females, ages 16-22 years, who had achieved sexual and skeletal maturity. Significant negative relations were present between serum 250HD and weight, BMI, and all imaging measures of body fat. Values for PTH were also inversely correlated to 250HD. In contrast, no relation was observed between circulating 250HD and CT or DXA measurements in the appendicular or axial skeleton. Similar relations were seen in the 53 (59%) women with vitamin D deficiency/insufficiency (less than or equal to 29 ng/ml), but were not present in the 37 (41%) with greater than or equal to 30 ng/ml vitamin D levels. In conclusion, we found strong negative relations between vitamin D values and measures of weight, BMI and body adiposity, but no relation with bone mass in young women.