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United States Department of Agriculture

Agricultural Research Service

Title: Genomic Islands in Pathogenic Filamentous Fungus Aspergillus fumigatus)

Author
item Fedorova, Natalie
item Khaldi, Nora
item Joardar, Vinita
item Maiti, Rama
item Amedeo, Paolo
item Anderson, Michael
item Crabtree, Jonathan
item Silva, Joana
item Badger, Jonathan
item Albarraq, Ahmed
item Angiuoli, Sam
item Bussey, Howard
item Bowyer, Paul
item Cotty, Peter
item Dyer, Paul
item Egan, Amy
item Galens, Kevin
item Fraser-liggett, Claire
item Haas, Brian
item Inman, Jason
item Kent, Richard
item Lemieux, Sebastien
item Malavazi, Iran
item Orvis, Joshua
item Roemer, Terry
item Ronning, Catherine
item Sundaram, Jaideep
item Sutton, Granger
item Turner, Geoff
item Venter, J. Craig
item White, Owen
item Whitty, Brett
item Youngman, Phil
item Wolfe, Kenneth
item Goldman, Gustavo
item Wortman, Jennifer
item Jiang, Bo
item Denning, David
item Nierman, William

Submitted to: PLoS Genetics
Publication Type: Review Article
Publication Acceptance Date: 3/4/2008
Publication Date: 4/11/2008
Citation: Fedorova, N.D., Khaldi, N., Joardar, V., Maiti, R., Amedeo, P., Anderson, M.J., Crabtree, J., Silva, J.C., Badger, J., Albarraq, A., Angiuoli, S., Bussey, H., Bowyer, P., Cotty, P.J., Dyer, P.S., Egan, A., Galens, K., Fraser-Liggett, C.M., Haas, B.J., Inman, J.M., Kent, R., Lemieux, S., Malavazi, I., Orvis, J., Roemer, T., Ronning, C.M., Sundaram, J.P., Sutton, G., Turner, G., Venter, J.C., White, O.R., Whitty, B.R., Youngman, P., Wolfe, K.H., Goldman, G.H., Wortman, J.R., Jiang, B., Denning, D.W., Nierman, W.C. 2008. Genomic Islands in the Pathogenic Filamentous Fungus Aspergillus fumigatus. PLoS Genetics. 4(4):e1000046:1-13

Interpretive Summary:

Technical Abstract: We present the genome sequences of a new clinical isolate, CEA10, of an important human pathogen, Aspergillus fumigatus, and two closely related, but rarely pathogenic species, Neosartorya fischeri NRRL181 and Aspergillus clavatus NRRL1. Comparative genomic analysis of CEA10 with the recently sequenced A. fumigatus isolate Af293 has identified core, variable and unique regions in each genome. While the core regions are 99.8% identical at the nucleotide level, identity over some variable regions can be as low 40%. Further comparison has revealed that A. fumigatus contains isolate- and species-specific genes, which comprise ~2% and 9% of the genome, respectively. These lineage-specific genes differ in variability, dispensability and size from the core genes and encode accessory functions. Subsequent phylogenetic analysis demonstrated that these genes emergence though duplication, accelerated diversification and/or gene loss (DDL). Most lineage-specific genes cluster in large chromosomal islands, which display a strong subtelomeric bias, have low gene density, and harbour a disproportionate number of pseudogenes, transposons and other repetitive elements. These regions may function as designated “gene dumps” and, simultaneously, as “gene factories”. Although A. fumigatus was chosen as the primary focus of this study, similar chromosomal structures were observed in the genomes of N. fischeri and A. clavatus, suggesting that all three species are poised for the rapid adaptation to heterogeneous environments such as soil, compost piles or a mammalian host.

Last Modified: 8/24/2016
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