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Title: Application of the BovineSNP50 assay for QTL mapping and prediction of genetic merit in Holstein cattle

item Van Tassell, Curtis - Curt
item Sonstegard, Tad
item Smith, Timothy - Tim

Submitted to: Plant and Animal Genome Conference Proceedings
Publication Type: Abstract Only
Publication Acceptance Date: 12/1/2007
Publication Date: 1/9/2008
Citation: Schnabel, R.D., Van Tassell, C.P., Matukumalli, L., Sonstegard, T.S., Smith, T.P., Moore, S.S., Lawley, C.T., Taylor, J.F. 2008. Application of the BovineSNP50 assay for QTL mapping and prediction of genetic merit in Holstein cattle. Plant and Animal Genome Conference Proceedings.

Interpretive Summary:

Technical Abstract: The previous fifteen years have produced numerous QTL mapping experiments aimed at the identification of causal or linked polymorphisms for use in marker assisted selection programs to increase the rate of genetic gain in livestock species. To date, very few causal mutations for QTL have been identified while there have been numerous reports of marker associations, some of which are currently being commercialized. The recent and ongoing whole genome sequencing of livestock species has begun to provide fundamental tools which will allow QTL mapping and marker assisted selection to move beyond traditional paradigms. The availability of genotyping assays with tens to hundreds of thousands of SNP loci will provide the ability to map QTL at unprecedented resolution in livestock and also may lead to strategies for implementing whole genome selection, which has been perceived as eliminating the need for QTL mapping and discovery. While QTL mapping within the context of whole genome selection may seem unnecessary, we believe that the best use of these technologies will be to simultaneously pursue both strategies. Results from genotyping four thousand Holstein bulls with the BovineSNP50 iSelect SNP chip will be presented to illustrate our strategy for merging QTL mapping with whole genome selection.