Location: Livestock Issues ResearchTitle: Stimulation of appetite and the growth, stress, and immune axes of weanling pigs by syndyphalin-33 Author
|Carroll, Jeffery - Jeff Carroll|
Submitted to: American Dairy Science Association Abstracts
Publication Type: Abstract Only
Publication Acceptance Date: 7/11/2008
Publication Date: 7/23/2008
Citation: Jenkins, S., Cooper, T., Roberts, M., Carroll, J.A., Mathew, A., Kattesh, H., Kojima, C. 2008. Stimulation of appetite and the growth, stress, and immune axes of weanling pigs by syndyphalin-33 [abstract]. Journal of Animal Science. 86(E.Suppl. 2):526. (Abstract #574) Interpretive Summary:
Technical Abstract: Parameters measuring growth, stress, and immune response in weanling pigs given the opiate tripeptide syndyphalin-33 (SD) were investigated in three separate trials. In the first trial, 8 nursing pigs were given SD (0.5 umol/kg, n = 4) or vehicle (VEH; n = 4) in a single im injection at 13 d of age and weaned 6 d later. Feed intake (FI) was greater (P < 0.05) in SD compared to VEH pigs 3 d postweaning, and a numerical increase in BW was observed in SD pigs from d 3 to d 7 postweaning. In the second trial, 8 pigs (19 d of age) were weaned, fitted with jugular catheters, and placed in individual pens. The following day, blood was collected at 30-min intervals for 9 h. Immediately following the second blood sample, pigs received either SD (n = 4) or VEH (n = 4) as in trial one. Feed intake (FI) and body weight (BW) were recorded daily for 7 d. No differences in FI or BW were noted at any time. Plasma cortisol levels and the free cortisol index were elevated (P < 0.05) in SD compared to VEH pigs from 3 to 4 h post-injection. Plasma corticosteroid-binding globulin levels were unchanged. Serum growth hormone concentrations were increased (P < 0.05) in SD pigs at 2 h post-injection. In the third trial, 8 pigs (19 d of age) were weaned, cannulated, and placed in individual pens. The next day, immediately following blood collection, pigs received either SD or VEH as above, and all pigs received an oral gavage of live Salmonella enterica. Blood was collected every 24 h for 4 d. The immune challenge increased (P < 0.05) the numbers of neutrophils, lymphocytes, and monocytes from 48 h post-challenge to the end of the sampling period. There was a further stimulatory effect of SD on circulating neutrophil and monocyte populations, resulting in an overall increase (P < 0.05) in total white blood cell number. Pigs given SD had similar FI and BW as VEH pigs as measured on d 19 to 23. A decrease (P < 0.05) in serum glucose levels was observed at 48 h in SD pigs. These results suggest that treatment with SD can affect many aspects of the physiology of weanling pigs, but the timing of injection relative to weaning may modulate the response.