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Title: Biologically Active Tetranorditerpenoids from Fungus Sclerotinia homoeocarpa Causal Agent of Dollar Spot in Turfgrass

Author
item HERATH, H.M.T. BANDARA - UNIVERSITY OF MISSISSIPPI
item HERATH, WIMAL H.M.W. - UNIVERSITY OF MISSISSIPPI
item CARVALHO, PAULO - UNIVERSITY OF MISSISSIPPI
item KHAN, SHABANA - UNIVERSITY OF MISSISSIPPI
item TEKWANI, BABU - UNIVERSITY OF MISSISSIPPI
item Duke, Stephen
item TOMASO-PETERSON, MARIA - MS STATE UNIVERSITY
item NANAYAKKARA, N.P. DHAMMIKA - UNIVERSITY OF MISSISSIPPI

Submitted to: Journal of Natural Products
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 10/2/2009
Publication Date: 11/23/2009
Citation: Herath, H., Herath, W., Carvalho, P., Khan, S.I., Tekwani, B., Duke, S.O., Tomaso-Peterson, M., Nanayakkara, N. 2009. Biologically Active Tetranorditerpenoids from Fungus Sclerotinia homoeocarpa Causal Agent of Dollar Spot in Turfgrass. Journal of Natural Products. 72:2091-2097.

Interpretive Summary: Nine new compounds and four previously reported ones were isolated from the an extract of the culture medium of the plant pathogen Sclerotinia homoeocarpa. Some of these compounds showed potent antimalarial and herbicidal activities.

Technical Abstract: Nine new tetranorditerpenoid dilactones (2-10), together with four previously reported norditerpenoids dilactones (1, 11), and two known putative biosynthetic intermediates oidiolactone-E (12) and 13 were isolated from the ethyl acetate extract of the culture medium of Sclerotinia homoeocarpa. Structures and relative stereochemistry of these compounds were determined by spectroscopic methods and further confirmed by X-ray crystallographic analysis of representative compounds. Some of these compounds showed potent antiplasmodial and phytotoxic activities. The potency of these activities could be correlated to their cytotoxicity which could be attributed to the presence of an a,B-unsaturated lactone ring in these compounds. Although compounds 6 and 9 showed potent antimalarial activity, their high cytotoxicity would preclude them as potential antimalarial agents.