Submitted to: Journal of Natural Products
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 11/24/2009
Publication Date: 3/1/2010
Citation: Schmidt, L.E., Deyrup, S.T., Baltrusaitis, J., Swenson, D.C., Wicklow, D.T., Gloer, J.B. 2010. Hymenopsins A and B and a Macrophorin Analogue from a Fungicolous Hymenopsis sp. Journal of Natural Products. 73(3):404-408. Interpretive Summary: Fungi that parasitize and kill other fungi offer a potential source of novel antifungal agents useful to agriculture and medicine. The fungus Hymenopsis sp. NRRL 37638, encountered as a colonist of a wood decay fungus in Hawaii, was examined for its ability to produce antifungal agents and other bioactive metabolites. Hymenopsin A & B are reported as new metabolites showing activity against Staphylococcus aureus and Bacillus subtilus while a new macrophorin metabolite was also active against Aspergillus flavus and Fusarium verticillioides.
Technical Abstract: Hymenopsin A (1), hymenopsin B (2), and a new macrophorin analogue, 2',3'-epoxy-13-hydroxy-4'-oxomacrophorin A (3), have been isolated from a fungicolous isolate of Hymenopsis sp. (NRRL 37638). The structures and relative configurations of these compounds were assigned on the basis of 2D NMR and MS data, and the identity of 1 was confirmed by X-ray crystallographic analysis. Compounds 2 and 3 showed antibacterial activity against Staphylococcus aureus and Bacillus subtilis. Compound 3 was also active against Aspergillus flavus and Fusarium verticillioides.