Submitted to: Journal of Nutrition
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 9/28/2007
Publication Date: 11/1/2007
Citation: Abrams, S.A., Griffin, I.J., Hawthorne, K.M. 2007. Young adolescents who respond to an inulin-type fructan substantially increase total absorbed calcium and daily calcium accretion to the skeleton. Journal of Nutrition. 137:2524S-2526S.
Interpretive Summary: We measured how much of the calcium in the diet was absorbed and the bone mineral content in adolescents who received a functional fiber called a prebiotic inulin-type fructan. We found that those who received the prebiotic had more absorption and stronger bones as evidenced by a higher bone mineral content. However, not everyone responded to it. The 2/3 who did respond had a substantial benefit that would be comparable to increasing daily calcium intake by about the amount of a glass of milk. Therefore, we believe that increasing intake of functional fibers, such as prebiotics, may be an important aspect of a multi-faceted approach to enhancing bone strength in adolescents.
Technical Abstract: Calcium absorption and whole-body bone mineral content are greater in young adolescents who receive 8 g/d of Synergy, a mixture of inulin-type fructans (ITF), compared with those who received a maltodextrin control. Not all adolescents responded to this intervention, however. We evaluated 32 responders and 16 nonresponders to the calcium absorptive benefits of ITF. We found no differences in usual dietary calcium intakes. Responders who increased their calcium absorption by at least 3% after 8 wk of Synergy had a greater accretion of calcium to the skeleton over a year based on whole-body dual-energy x-ray absorptiometry data. The absorptive benefit to ITF use in responders is substantial and would be comparable to increasing daily calcium intake by at least 250 mg. Increased intake of ITF may be an important aspect of a multifaceted approach to enhancing peak bone mass.