Submitted to: Journal of Essential Oil Research
Publication Type: Peer reviewed journal
Publication Acceptance Date: 8/14/2007
Publication Date: 6/7/2010
Citation: Takeoka, G.R., Hobbs, C., Park, B.-S. 2010. Volatile Constituents of the Aerial Parts of Salvia apiana Jepson. Journal of Essential Oil Research. 22: 241-244. Interpretive Summary: Plants of the important Salvia genus (Lamiaceae) are widely distributed throughout the world and are represented by about 900 species. These plants are used in traditional and folk medicine for the treatment of coronary heart disease, cerebrovascular disease, hepatitis, heptaocirrhosis, chronic renal failure, dysmenorrheal and neuroasthenic insomnia. Extracts and constituents isolated from Salvia species have been found to possess important biological activities, including antibacterial, antiviral, antiplatelet, antitumor, anti-inflammatory, antihydrotic and antioxidant activities. Previous studies on these plants have revealed that constituents such as phenolic acids, phenolic glycosides, flavonoids, anthocyanins, coumarins, polysaccharides, sterols and terpenoids are present in different parts of the plant. In our continuing search for biologically active natural constituents, we investigated the volatiles in the aerial parts of S. apiana. We identified a total of 84 constituents in S. apiana. Our next step is to study the biological activity of the identified constituents.
Technical Abstract: Volatile constituents of the aerial parts of fresh white sage (Salvia apiana) were isolated by extraction with diethyl ether followed by high vacuum distillation with a solvent assisted flavor evaporation (SAFE) apparatus. The isolated volatiles were analyzed by GC and GC/MS. A total of 84 constituents were identified (constituting 95.1% of the total area), 11 of which were tentatively identified. The volatiles were characterized by a high content of hydrocarbon and oxygenated monoterpenes. The major constituents identified were 1,8-cineole (34.5%), camphor (21.7%), beta-pinene (7.4%), alpha-pinene (6.4%), delta-3-carene (6.4%), camphene (3.9%), limonene (3.5%), myrcene (3.2%), and alpha-terpinolene (1.3%).