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Title: Avian influenza virus-induced regulation of duck fibroblast gene expression

Author
item Sarmento, Luciana
item Wasilenko, Jamie
item Pantin-Jackwood, Mary

Submitted to: American Association of Avian Pathologists
Publication Type: Abstract Only
Publication Acceptance Date: 1/15/2008
Publication Date: 7/20/2008
Citation: Sarmento, L., Wasilenko, J.L., Pantin Jackwood, M.J. 2008. Avian influenza virus-induced regulation of duck fibroblast gene expression [abstract]. 145th American Veterinary Medical Association Annual Meeting, July 20-22, 2008, New Orleans, Louisiana. 2008 CDROM.

Interpretive Summary:

Technical Abstract: Highly pathogenic avian influenza (HPAI) H5N1 viruses have been non-pathogenic in ducks causing no disease or mild respiratory infections. However, in 2002, new viruses emerged causing systemic disease and death. To better understand the differences in pathogenicity of HPAI viruses in ducks, we investigated the ability of wild-type and recombinant viruses to replicate in duck fibroblasts. In addition, differences in host gene expression were accessed by semi-quantitive RT-PCR. Substantial differences in the expression of IFN-a, Mx1 and IL-8 genes were found. Our results suggest that differences in cellular gene expression may contribute to the differences in avian influenza virus replication.