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ARS Home » Southeast Area » Little Rock, Arkansas » Arkansas Children's Nutrition Center » Research » Publications at this Location » Publication #218696

Title: Correction of dyslipidemia resulting from high fat diets with purified anthocyanins from blueberry or strawberry but not in context of the complete berry

Author
item Prior, Ronald
item Wilkes, Samuel
item Wu, Xianli

Submitted to: Federation of American Societies for Experimental Biology Conference
Publication Type: Abstract Only
Publication Acceptance Date: 1/29/2008
Publication Date: 4/9/2008
Citation: Prior, R.L., Wilkes, S., Wu, X. 2008. Correction of dyslipidemia resulting from high fat diets with purified anthocyanins from blueberry or strawberry but not in context of the complete berry [abstract]. The FASEB Journal. 22:460.2.

Interpretive Summary: Obesity is becoming an epidemic throughout the world. Understanding of factors in foods that may alter or prevent the development of obesity is important. An animal model of obesity was used in this study involved feeding male C57BL/6 mice diets containing either a low or high level of fat. In the first study the diets were prepared with or without freeze dried powders from whole blueberries or strawberries. In the second study, a low fat or high fat diet was fed and purified anthocyanins from strawberries or blueberries were added to the drinking water of the treatment groups fed the high fat diet. When whole strawberry or blueberry powder was included in the diet, plasma triglycerides were increased by feeding the HF diet but were elevated further when blueberry was included in the high fat diet. Liver total lipids and triglycerides were increased in mice fed the high fat diet but were not altered by either SB or BB in the diet. Mice fed the high fat diet plus purified anthocyanins from blueberry in the water had lower body weight gains and body fat than the high fat fed controls without blueberry. Plasma cholesterol and triglyceride levels were elevated with a high fat diet and decreased to control levels when anthocyanins from either strawberries or blueberries were included in the drinking water. Purified anthocyanins prevented the development of obesity, but not in the context of the whole berry.

Technical Abstract: Male C57BL/6 mice received diets with either 10% of kcal from fat (LF), a high fat diet [45% (HF45) or 60% (HF60) kcal from fat]. In the first study the diets were prepared with or without freeze dried powders from whole blueberries (BB) and strawberries (SB). In the 2nd study, a LF or HF60 diet was fed and purified anthocyanins (ACNs) from SB or BB (1 mg total ACN/mL) were added to the drinking water of the treatment groups fed HF60 diet. In Study 1, when whole SB or BB powder was included in the diet, plasma triglycerides were increased by feeding the HF diet but were elevated further when BB was included in the HF diet. Liver total lipids and triglycerides were increased in mice fed HF diet but were not altered by either SB or BB in the diet. Liver cholesterol was not altered by dietary fat level or SB or BB in the diet. In the 2nd study, after 8 weeks mice fed the HF60 diet plus purified ACNs from BB in the water, had lower body weight gains and body fat than the HF60 fed controls. Remarkably, plasma cholesterol (mg/dL) was 128 plus/minus 11.7, 237.6 +/- 19.5, 151.3 +/- 18.4, and 166 +/- 9.8, and triglycerides (mg/dL) were 172.8 +/- 22.8, 311.6 +/- 38.6, 168.4 +/- 15.9, and 153.6 +/- 33.2 in LF Control, HF60, HF60-BB, and HF60-SB, respectively. Plasma cholesterol and triglyceride levels were elevated with a high fat diet and decreased to control levels when ACNs from either SB or BB were included in the drinking water. Purified anthocyanins prevented the development of obesity, but not in the context of the whole berry.