Submitted to: Experimental Biology
Publication Type: Abstract Only
Publication Acceptance Date: 2/15/2008
Publication Date: 3/15/2008
Citation: Dopler-Nelson, M., Burri, B.J., Neidlinger, T.R., Stanhope, K., Havel, P.J. 2008. Prevalence of Oxidative Stress and Metabolic Syndrome in Adults with Paraplegia and Tetraplegia. Experimental Biology.
Technical Abstract: Objectives: To investigate the extent of oxidative stress and metabolic syndrome (MetS) in people with spinal cord injuries (SCI) and to identify the major factors associated with oxidative stress and MetS in this population. Methods: 24 subjects with paraplegia (PARA), 26 subjects with tetraplegia (TETRA), and 28 able-bodied controls (CNTL) were recruited from Northern California. MetS was defined as having > 3 of the following components: (a) BMI > 30.0 kg/m2; (b) fasting HDL <40 mg/dL males; <50 mg/dL females; (c) fasting triglyceride >150 mg/dL; (d) > 130mmHg systolic (SBP) or > 85mmHg diastolic blood pressure (DBP) (e) fasting glucose 100-125 mg/dL, fasting insulin > 20uU /mL, or insulin resistance > 4.0. Antioxidant activity was measured using vitamin E and TBARS. Results: Subjects with SCI had greater incidence of MetS than CNTL (29.2% of PARA, 15.4% of TETRA, and 3.6% of CNTL.) MetS was not significantly correlated with vitamin E or TBARS. Location of spinal cord lesion correlated with SBP (r=0.522; p<0.0001) and DBP (r=0.319; p=0.026). TBARS was 20.3% higher in PARA with lesions at L3-L4 than in TETRA with C2-C5 lesions (p=0.044). Conclusion: People with SCI are at greater risk for MetS than CNTL and location of spinal cord lesion may contribute to this risk.