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Title: Orange juice consumed regularly decreased the Insulin Resistance in normal subjects

Author
item RODRIGUES, LAYANE - SAO PAULO ST UNIV, BRAZIL
item PEREZ, MILENA - SAO PAULO ST UNIV, BRAZIL
item BONIFACIO, NANCY - SAO PAULO ST UNIV, BRAZIL

Submitted to: Subtropical Technology Conference Proceedings
Publication Type: Abstract Only
Publication Acceptance Date: 9/15/2007
Publication Date: 10/18/2007
Citation: Cesar, T.B., Rodrigues, L.U., Perez, M.S., Bonifacio, N.A. 2007. Orange juice consumed regularly decreased the insulin resistance in normal subjects. Subtropical Technology Conference Proceedings. 58:34.

Interpretive Summary:

Technical Abstract: Orange juice is a natural source of citrus flavonoids, that can protect against coronary heart disease (CHD) and cancer, and it can be easily incorporated into a healthy diet. In spite of this, orange juice is also associated with high sugar intake (glucose and fructose) that can increase insulin resistance and lead to diabetes and its complications. The objective of this study was to evaluate the effect of routine consumption of orange juice on the insulin resistance (IR) determined by Homa Index and to analyze the relation to other components of the metabolic syndrome. We studied 30 non-diabetic individuals (15 men and 15 women), aged between 25 and 55 years, randomly selected among students and employees of a Phramaceutical School in Araraquara, SP, Brazil. They volunteered to drink 750mL/day of orange juice, without added sugar, during 60 days. The HOMA index was calculated as fasting insulin concentration (µU/mL) x fasting glucose concentration (mmol/L) / 22.5. In addition it was measured by standard methods in all subjects: anthropometric parameters and blood lipids levels. Measurements of fasting glucose and insulin in the beginning of the experiment were respectively: 4.45 mmol/L and 7.75 µU/mL, and after 60 days: 4.53 mmol/L and 6.55 µU/mL. HOMA index calculated for the first day of orange juice consumption was: 1.54 ± 0.9, and after 60 days was: 1.33 ± 0.8 (p< 0.01). At the end of experiment, total cholesterol, LDL-c and HDL-c decreased by 10%, 14% and 6% respectively (p< 0.01), while triglycerides were not changed (p= 0.19). The significant decrease of 14% of HOMA Index was associated with a reduction of Insulin Resistance after 60 days of consumption of orange juice in non-diabetic individuals. In addition, the biochemical indicators: serum glucose, insulin, LDL-c and triglycerides (TG) showed that orange juice did not increase the risk for diabetes or coronary heart disease.