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United States Department of Agriculture

Agricultural Research Service

Title: A comparison of the effect of water-delivered direct fed microbials or organic acids with an in-feed antibiotic on weanling pig growth performance, intestinal morphology, gut microbiota and immune status following a...)

Author
item Walsh, M
item Sholly, D
item Saddoris, K
item Aldridge, B
item Sutton, A
item Rostagno, Marcos
item Richert, B
item Radcliffe, J

Submitted to: Joint Meeting of the ADSA, AMSA, ASAS and PSA
Publication Type: Abstract Only
Publication Acceptance Date: 4/23/2007
Publication Date: 7/8/2007
Citation: Walsh, M.C., Sholly, D.M., Saddoris, K.L., Aldridge, B.E., Sutton, A.L., Rostagno, M.H., Richert, B.T., Radcliffe, J.S. 2007. A comparison of the effect of water-delivered direct fed microbials or organic acids with an in-feed antibiotic on weanling pig growth performance, intestinal morphology, gut microbiota and immune status following a Salmonella Typhimurium challenge. Joint Meeting of the ADSA, AMSA, ASAS and PSA. p. 646.

Interpretive Summary:

Technical Abstract: Pigs (n=88) weaned at 19 days of age were used in a 14-days experiment to compare the effects of water delivered direct fed microbials (DFM) or a propionic acid (PA) based blend with an in-feed antibiotic on growth performance, intestinal morphology, gut microbiota and immune status following a Salmonella Typhimurium challenge. Treatments were: 1) negative control (NC), 2) Treatment 1 + water-supplied DFM (Enterococcus faecium, Bacillus subtilis, and Bacillus licheniformis), 3) Treatment 1 + water-supplied PA blend, and 4) treatment 1 + in-feed antibiotic (Carbadox). Pigs were challenged intranasally with Salmonella Typhimurium on day 6 post-weaning, and harvested on day 6 (prior to challenge), 8, 10, and 14 post-weaning. Water-delivered DFM, PA blend or in-feed antibiotic improved ADG (P<0.05) on days 2-4 post-challenge compared to NC pigs. Water-delivered DFM tended (P<0.10) to increase G:F on days 0-5 pre-challenge compared to NC pigs. Water-delivered DFM increased (P<0.05) duodenal villus height on day 4 post-challenge compared to pigs receiving carbadox or in the NC treatment. Water-delivered PA blend tended (P<0.10) to decrease Enterobacteriaceae counts in the cecum on days 0 and 2 post-challenge compared to the DFM treatment. Salmonella presence in the ileum, cecum and mesenteric lymph nodes was not different among treatments at any time-point post-challenge. However, the proportion of pigs shedding Salmonella in the feces was decreased 100 and 50% by DFM and PA blend treatments, respectively, on day 5 post-challenge. There were no treatment differences in TNF-alpha concentration in serum, duodenal, jejunal, or ileal tissue at any time-point post-challenge. However, serum TNF-alpha concentration increased linearly (P<0.04) through day 4 post-challenge for all treatments. Treatments had no effect on microbial presence and/or concentration in the gastrointestinal tract, but did improve growth performance and intestinal morphology following a Salmonella challenge.

Last Modified: 8/24/2016
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