|Goosby Landry, Latrice|
Submitted to: Annual Conference on Cardiovascular Disease Epidemiology and Prevention
Publication Type: Abstract Only
Publication Acceptance Date: 12/8/2006
Publication Date: 2/27/2007
Citation: Goosby Landry, L., Wilson, J.G., Lichtenstein, A.H., Ordovas, J.M., Tucker, K., Taylor, H.A., Destefano, A.L. 2007. Heritability of Lipid Phenotypes among African-Americans: Jackson Heart Study. Annual Conference on Cardiovascular Disease Epidemiology and Prevention. 115:e300. Interpretive Summary:
Technical Abstract: Determinants of serum lipid levels include both genetic and non-genetic components. More research is needed to determine the role each plays in serum lipid levels of African-Americans. The Jackson Heart Study Family Sub-Study (JHS, FSS) represents a cohort of African-American adults for which both plasma lipid and lifestyle data are available.Using Solar 2.1.4 genetics software, heritability estimates were calculated for adjusted and non-adjusted lipid phenotypes in 1546 African-American adults participating in the JHS, FSS (310 pedigrees), age 21-95 years. Phenotypes included high density lipoprotein-C (HDL), low density lipoprotein-C (LDL), triglycerides (TG), total cholesterol (TC) and TC:HDL C ratio. Adjustments were made for age, sex, body mass index (BMI) and waist circumference (WC), as well as dietary cholesterol, saturated fatty-acids, poly-unsaturated fatty-acids and dietary fiber as covariates. BMI, WC, age and sex were found to be significant covariates however effects of these factors were altered by inclusion of dietary factors. Differences among models using BMI and those with WC were minimal. Estimates of heritability for HDL, LDL, TG, TC and TC:HDL C ranged between .4 and .5 when adjusted for BMI or WC, sex and age. Some Heritability estimates were affected by inclusion of dietary covariates. Heritability estimates for TG were lower with inclusion of diet variables. There is a significant genetic component in serum lipid levels for this JHS cohort after adjustment for BMI or WC, sex and age. The heritability estimates observed are comparable to those previously reported for other cohorts. In particular, we found that inclusion of dietary factors affects these estimates, as well as the significance of non-diet covariates.