|Hong, Yun Jeong|
|Yokoyama, Wallace - Wally|
Submitted to: International Conference & Exhibition of Nutraceuticals & Functional Foods
Publication Type: Proceedings
Publication Acceptance Date: 11/5/2006
Publication Date: 11/5/2006
Citation: Hong, Y., Yokoyama, W.H., Turowski, M. 2006. Modified Celluloses Improve Plasma Lipid Profile of Hamsters by Modifying Fecal Lipid Excretion. International Conference & Exhibition of Nutraceuticals & Functional Foods. Session 561-565.
Interpretive Summary: There is no interpretive summary for this presentation.
Technical Abstract: Soluble dietary fibers can have a profound effect on plasma cholesterol, triglycerides, glucose and insulin concentrations. Soluble celluloses are some of the most potent soluble fibers. They are not fermented and are not absorbed into the blood stream. We have reported recently that compared to Teflon, a completely inert, nonviscous material, even microcrystalline cellulose affects plasma lipids. Soluble celluloses may exert their physiological activity through binding bile acids and/or sterols, inhibiting lipase, or disrupting fat micelles in the intestinal lumen. The products of these different mechanisms are evident in the excreted lipids. An HPLC method was developed to simultaneously analyze for phospholipids, bile acids, sterols, and mono-, di-, and triglycerides. The chromatographic method utilizes gradient elution of a C18 column and evaporative light scattering detection. Earlier analysis of feces often overlooked more or less polar compounds, concentrating on sterols and bile acids.