Submitted to: Journal of the Science of Food and Agriculture
Publication Type: Review article
Publication Acceptance Date: 8/3/2006
Publication Date: 9/28/2006
Citation: Lau, F.C., Shukitt Hale, B., Joseph, J.A. 2006. Beneficial effects of berryfruit polyphenols on neuronal behavioral aging. Journal of the Science of Food and Agriculture.86:2251-2255. Interpretive Summary:
Technical Abstract: It is becoming increasingly clear that although there is a great deal of research being devoted to elucidating the molecular mechanisms involved in aging, practical information on how to forestall or reverse the deleterious effects of aging may be years away. Therefore, it may be beneficial to determine other methods to improve the quality of life in the aging population. A plethora of epidemiological studies have indicated that individuals who consume a diet containing high amounts of fruits and vegetables may have a reduced incidence of age-associated diseases such as cardiovascular or neurodegenerative diseases. Research from our laboratory has suggested that supplementation with fruit or vegetable extracts high in antioxidants can decrease the enhanced vulnerability to oxidative stress and inflammation that occurs in aging, and that these reductions are expressed as improvements in behavior. In addition to research indicating the antioxidant or anti-inflammatory functions of the polyphenolic compounds found in these fruits and vegetables, further studies have suggested that other mechanisms such as cellular signaling may contribute to the beneficial effects of these compounds on aging.