Submitted to: Book Chapter
Publication Type: Book / Chapter
Publication Acceptance Date: 2/14/2004
Publication Date: 3/20/2006
Citation: Heird, W.C. 2006. Intravenous feeding. In: Thureen, P., Hay, W., editors. Neonatal Nutrition and Metabolism. 2nd Edition. NY: Cambridge University Press. p. 312-331. Interpretive Summary:
Technical Abstract: Total parenteral nutrition as practiced today was not a part of modern medicine until the late 1960s. Having demonstrated that normal growth of puppies could be achieved solely with parenterally administered nutrients, Dudrick et al. adapted the technique used in animals for clinical use. Shortly thereafter, Wilmore and Dudrick described use of this new technique in treatment of an infant who had virtually no remaining small intestine and, therefore, was totally dependent upon parenterally delivered nutrients. Although the infant eventually succumbed, normal growth and development was maintained for several months solely with parenterally delivered nutrients. By the late 1800s the potentially deleterious effects of catabolism and starvation were recognized, rekindling interest in ability to provide nutrients parenterally. This resulted in development of products that could be delivered parenterally and, by the early 1940s, glucose and protein hydrolysates that could be delivered safely by the parenteral route were available.