Submitted to: Plant and Animal Genome VX Conference Abstracts
Publication Type: Abstract only
Publication Acceptance Date: 11/2/2006
Publication Date: 1/13/2007
Publication URL: http://www.intl-pag.org/15/abstracts/PAG15_W67_426.html
Citation: Lunney, J.K. 2006. Advances in Swine Biomedical Model Genomics. Proceedings Swine Genome Workshop "Advances in Swine Genome Science and Biotechnology" [Abstracts] Plant and Animal Genome VX Conference 2007. Available: http://www.intl-pag.org/15/abstracts/PAG15_W67_426.html Interpretive Summary:
Technical Abstract: The swine has been a major biomedical model species, for transplantation, heart disease, allergies and asthma, as well as normal neonatal development and reproductive physiology. Swine have been used extensively for studies of infectious disease processes and analyses of preventative strategies, including test of vaccines and their adjuvants, as well as effects of biotherapeutics. Local mucosal tissue development and responses to infection can be monitored in normal and in gnotobiotic piglets, affirming the role of tissue and immune activation in disease responses. Recent advances in swine genome sequencing and availability of genomic tools, e.g., microarrays and realtime assays of gene expression, SNPs and microsatellites for genome mapping, along with evolving tools for proteomic analyses have enabled researchers to assess genomic influences in these models. This review will discuss new approaches being used to probe pathways regulating normal development as well as disease processes. It will highlight opportunities that are now open to more fully explore these swine biomedical models using genomic tools.