Submitted to: Trade Journal Publication
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 9/15/2006
Publication Date: 10/1/2006
Citation: Lee, S., Park, H., Cho, S., Jung, H., Cho, S., Lillehoj, H.S. 2006. Supplementary effect by harvest period of Lentinus edodes on the levels of blood glucose and serum lipid in diabetic KK mice. J. Korean Soc. Food. Sci. Nutr. 34:738-742. Interpretive Summary: In this paper, ARS scientists collaborated with scientists at the Rural Development Administration of South Korean government to establish an animal model system to study the effect of dietary supplementation of Lentinus edodes (LE) on blood glucose and serum lipid levels. The results showed that Lentinus edodes harvested at different times of maturity exerted beneficial effects on the diabetic mice. These results clearly demonstrate that Lentinus edodes, regardless of their harvested period reduced body weight and serum lipid without affecting blood glucose level in diabetic mice. The results of this study provide important information on the role of dietary supplements on human health.
Technical Abstract: This study was carried out to investigate the effect of Lentinus edodes which were harvested at different times of maturity on blood glucose and lipid levels in diabetic mice. The diabetic KK mice were fed diet supplemented with Lentinus edodes harvested early (LE) or late (LL) for eight weeks, and control (CO) mice were fed regular diet without Lentinus edodes. Diet intake, body weight, organ weight, blood glucose and serum lipid levels were measured. The mice which were fed diets supplemented with LE and LL showed significantly lower body weights compared to the CO group. There were no significant differences in the diet intake and the weights of different organs including liver, heart, kidneys, and epididymal fat pad among the three different groups. Furthermore, the concentrations of serum triglycerides and total cholesterol were significantly lower in LE and LL groups compared to the CO group. These results clearly demonstrate that Lentinus edodes, regardless of their harvested period, reduced body weight and serum lipid without affecting blood glucose level in diabetic mice.