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Title: Biological Stress Response Terminology: Integrating the Concepts of Adaptive Response and Preconditioning Stress Within a Hormetic Dose-Response Framework

item Calabrese, Edward
item Bailer, A. John
item Bachmann, Kenneth
item Bolger, P. Michael
item Borak, Jonathan
item Cai, Lu
item Cedergreen, Nina
item Chiueh, Chuang
item Cherian, M. George
item Clarkson, Thomas
item Cook, Ralph
item Diamond, David
item Doolittle, David
item Dorato, Michael
item Duke, Stephen
item Feinendegen, Ludwig
item Gardner, Donald
item Hart, Ronald
item Hastings, Kenneth
item Hayes, A
item Hoffman, George
item Jaworowski, Zbigniew
item Johnson, Thomas
item Keller, John
item Klaunig, James
item Knudsen, Thomas
item Kozumbo, Walter
item Lettieri, Teresa
item Liu, Shu-zheng
item Maisseu, Andre
item Maynard, Kenneth
item Masoro, Edward
item Mothersil, Carmel
item Newlin, David
item Oehme, Frederick
item Phalen, Robert
item Philbert, Martin
item Rattan, Suresh I.s.
item Riviere, Jim
item Rodricks, Joseph
item Sapolsky, Robert
item Scott, Bobby
item Seymour, Colin
item Smith-sonneborn, Joan
item Snow, Elizabeth
item Spear, Linda
item Stevenson, Donald
item Thomas, Yolene
item Williams, Gary
item Mattson, Mark

Submitted to: Journal of Toxicology and Applied Pharmacology
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 2/26/2007
Publication Date: 3/7/2007
Citation: Calabrese, E.J., Bailer, A., Bachmann, K.A., Bolger, P., Borak, J., Cai, L., Cedergreen, N., Chiueh, C.C., Cherian, M., Clarkson, T.W., Cook, R.R., Diamond, D.M., Doolittle, D.J., Dorato, M.A., Duke, S.O., Feinendegen, L., Gardner, D.E., Hart, R.W., Hastings, K.L., Hayes, A.W., Hoffman, G.R., Jaworowski, Z., Johnson, T.E., Keller, J.G., Klaunig, J.E., Knudsen, T.B., Kozumbo, W.J., Lettieri, T., Liu, S., Maisseu, A., Maynard, K., Masoro, E.J., Mothersil, C., Newlin, D.B., Oehme, F.W., Phalen, R.F., Philbert, M.A., Rattan, S., Riviere, J.E., Rodricks, J., Sapolsky, R.M., Scott, B.R., Seymour, C., Smith-Sonneborn, J., Snow, E.T., Spear, L., Stevenson, D.E., Thomas, Y., Williams, G.M., Mattson, M.P. 2007. Biological Stress Response Terminology: Integrating the Concepts of Adaptive Response and Preconditioning Stress Within a Hormetic Dose-Response Framework. Journal of Toxicology and Applied Pharmacology. 222:122-128.

Interpretive Summary: Hormesis is the stimulatory effect of a subtoxic level of a toxin. Terminology regarding this and related phenomena is not uniform, causing confusion. This paper, with authors from all areas of medicine, bioscience, and toxicology, provides a uniform terminology for hormesis and related phenomena.

Technical Abstract: Many biological subdisciplines that regularly assess dose-response relationships have identified an evolutionarily conserved process in which a low dose of a stressful stimulus activates an adaptive response that increases the resistance of the cell or organism to a moderate to severe level of stress. Due to a lack of frequent interaction among scientists in these many areas, there has emerged a broad range of terms that describe such dose-response relationships. This situation has become problematic because the different terms describe a family of similar biological responses (e.g., adaptive response, preconditioning, hormesis), adversely affecting interdisciplinary communication, and possibly even obscuring generalizable features and central biological concepts. With support from scientists in a broad range of disciplines, this article offers a set of recommendations we believe can achieve greater conceptual harmony in dose- response terminology, as well as better understanding and communication across the broad spectrum of biological disciplines.