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United States Department of Agriculture

Agricultural Research Service

Title: SPORMINARINS A AND B: ANTIFUNGAL METABOLITES FROM A FUNGICOLOUS ISOLATE OF SPORORMIELLA MINIMOIDES.)

Author
item Mudur, Sanjay
item Gloer, James
item Wicklow, Donald

Submitted to: Journal of Antibiotics
Publication Type: Peer reviewed journal
Publication Acceptance Date: 8/16/2006
Publication Date: 8/30/2006
Citation: Mudur, S.V., Gloer, J.B., Wicklow, D.T. 2006. Sporminarins A and B: antifungal metabolites from a fungicolous isolate of sporormiella minimoides. Journal of Antibiotics. 59(8):500-506.

Interpretive Summary: Fungi that parasitize and kill other fungi offer a potential source of novel antifungal agents useful to agriculture and medicine. The fungus Sporormiella minimoides NRRL 37629, encountered as a colonist of a wood decay fungus growing on a dead hardwood branch, collected in a subalpine forest in Hawaii County, Hawaii, was examined for its ability to produce antifungal agents and other bioactive metabolites. Sporminarin A is reported as a new fungal metabolite with significant antifungal activity against Aspergillus flavus.

Technical Abstract: Cultures of a fungicolous isolate of Sporormiella minimoides afforded two new polyketide metabolites which we have named sporminarins A (1) and B (2). The planar structures of 1 and 2 were elucidated by analysis of NMR and MS data, and by chemical methods. Sporminarin A (1) exhibited significant antifungal activity against Aspergillus flavus.

Last Modified: 8/24/2016
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