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United States Department of Agriculture

Agricultural Research Service


item Tyler, Brett
item Tripathy, Sucheta
item Zhang, Xuemin
item Dehal, Paramvir
item Jiang, Rays
item Aerts, Andrea
item Arredondo, Felipe
item Baxter, Laura
item Bensasson, Douda
item Beynon, Jim
item Chapman, Jarrod
item Damasceno, Cynthia
item Dorrance, Anne
item Dou, Daolong
item Dickerman, Allan
item Dubchak, Inna
item Garbelotto, Matteo
item Gijzen, Mark
item Gordon, Stuart
item Govers, Francine
item Grunwald, Niklaus - Nik
item Huang, Wayne
item Ivors, Kelly
item Jones, Richard
item Kamoun, Sophien
item Krampis, Konstantinos
item Lamour, Kurt
item Lee, Mi-kyung
item Maclean, Donald
item Mcdonald, W
item Medina, Monica
item Meiger, Harold
item Morris, Paul
item Nordberg, Eric
item Ospina-giraldo, Manuel
item Phuntumart, Vipaporn
item Putnam, Nicholas
item Rash, Sam
item Rose, Jocelyn
item Sakihama, Yasuko
item Salamov, Asaf
item Savidor, Alon
item Scheuring, Chantel
item Smith, Brian
item Sobral, Bruno
item Terry, Astrid
item Torto-alalibo, Trudy
item Win, Joe
item Xu, Zhanyou
item Zhang, Hongbin
item Grigoriev, Igor
item Rokhsar, Daniel
item Boore, Jeffrey

Submitted to: Science
Publication Type: Peer reviewed journal
Publication Acceptance Date: 7/18/2006
Publication Date: 9/1/2006
Citation: Tyler, B.M., Tripathy, S., Zhang, X., Dehal, P., Jiang, R.H., Aerts, A., Arredondo, F.D., Baxter, L., Bensasson, D., Beynon, J.L., Chapman, J., Damasceno, C.M., Dorrance, A.E., Dou, D., Dickerman, A.W., Dubchak, I.L., Garbelotto, M., Gijzen, M., Gordon, S.G., Govers, F., Grunwald, N.J., Huang, W., Ivors, K.L., Jones, R.W., Kamoun, S., Krampis, K., Lamour, K.H., Lee, M., Maclean, D.J., Mcdonald, W.H., Medina, M., Meiger, H.J., Morris, P.F., Nordberg, E.K., Ospina-Giraldo, M.D., Phuntumart, V., Putnam, N.H., Rash, S., Rose, J.K., Sakihama, Y., Salamov, A.A., Savidor, A., Scheuring, C.F., Smith, B.M., Sobral, B.W., Terry, A., Torto-Alalibo, T.A., Win, J., Xu, Z., Zhang, H., Grigoriev, I.V., Rokhsar, D.S., Boore, J.L. 2006. Phytophthora genome sequences uncover evolutionary origins and mechanisms of pathogenesis. Science. 313:1261-1266.

Interpretive Summary: Phytophthora pathogens are among the most notorious and economically important plant pathogens known to mankind. Among these we count the potato late blight pathogen, Phytophthora infestans, responsible for causing the Irish potato famine and the Sudden Oak Death (SOD) pathogen, Phytophthora ramorum, responsible for large scale mortality in West coast oak forests. The whole genome sequences of two Phytophthora pathogens, namely the soybean pathogen P. sojae and the SOD pathogen P. ramorum, were contrasted. The genome sequences of P. sojae and P. ramorum have yielded novel and important insights into both the evolution of this group of eukaryotes most closely related to algae and their potential mechanisms of pathogenicity. The genomes reveal that the pathogens contain many hundreds of rapidly evolving genes encoding pathogenicity factors involved in disease establishment and development. In addition, this work also provided the opportunity for development of molecular tools to monitor the migration and evolution of the SOD pathogen that is crucial to management of the SOD epidemic.

Technical Abstract: Draft genome sequences of the soybean pathogen Phytophthora sojae and the sudden oak death pathogen Phytophthora ramorum have been determined to depths of 9x and 7.7x, respectively. Oomycetes such as these Phytophthora species share the kingdom Stramenopiles with photosynthetic algae such as diatoms, and the Phytophthora sequences suggest that the kingdom's ancestor harbored a photosynthetic endosymbiont. Comparison of the two species' genomes reveals a rapid expansion and diversification of protein families associated with plant infection such as hydrolases, ABC transporters, protein toxins, proteinase inhibitors and in particular a superfamily of 700 proteins with similarity to known oomycete avirulence genes.

Last Modified: 8/24/2016
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