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United States Department of Agriculture

Agricultural Research Service

Title: DEGRADATION OF ESTRADIOL AND ETHINYLESTRADIOL WITH TAML OXIDANT ACTIVATOR AND HYDROGEN PEROXIDE.)

Author
item Shappell, Nancy
item Ro, Kyoung
item Madsen, Peter
item Horowitz, Colin
item Hunt, Patrick
item Collins, Terrence
item Vrabel, Melanie

Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 3/6/2006
Publication Date: 6/26/2006
Citation: Shappell, N.W., Ro, K.S., Madsen, P., Horowitz, C., Hunt, P.G., Collins, T.J., Vrabel, M. 2006. Degradation of estradiol and ethinylestradiol with taml oxidant activator and hydrogen peroxide. Meeting Abstract. 10th Annual Green Chemistry & Engineering Conference, Washington, DC, June 26-30, 2006.

Interpretive Summary:

Technical Abstract: Endocrine disruptors have been found in our surface waters as a result of incomplete wastewater treatment and contamination from animal rearing facilities. Two identified contaminants with estrogenic activity are 17ß-estradiol (E2, the most potent natural estrogenic hormone) and 17alpha-ethinylestradiol (EE2, the synthetic estrogen found in most birth control pills). A peroxide-activating catalyst Fe-TAML® (TAML® is tetraamido macrocyclic ligand) was evaluated for its capacity to degrade these compounds. While EE2 is resistant to most biological degradation processes, the Fe-TAML catalyst plus hydrogen peroxide (pH 10) resulted in degradation of greater than or equal to 95% within 5 minutes at room temperature (by HPLC analysis). Similar degradation was observed with E2 when the Fe-TAML:E2 ratio was 1:250, while degradation kinetics were measurable using ratios of 1:1000. The reaction closely followed first-order decay kinetics. Using LC MS-MS, neither estrogenic metabolite estrone nor estradiol were detected post-reaction. These results indicate a potential use for Fe-TAML in remediation of municipal and agricultural wastewater containing estrogenic compounds.

Last Modified: 8/24/2016
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