Submitted to: Experimental Biology
Publication Type: Abstract Only
Publication Acceptance Date: 11/15/2005
Publication Date: 4/1/2006
Citation: Shen, J., Crosier, M.D., Parnell, L.D., Shea, K., Dawson-Hughes, B., Ordovas, J.M., Booth, S.L. 2006. Interleukin 6-174c>g polymorphism is associated with low bone mineral density in older subjects consuming low calcium. Experimental Biology 2006 Annual Meeting. April 1- 5, 2006. San Francisco, CA. Abstract no. 398.1.
Technical Abstract: Interleukin 6 (IL6) is a pleiotropic proinflammtory cytokine that influences bone turnover. A common genetic variant at IL6 locus (-174C>G) has been inconsistently associated with low bone mineral density (BMD). The interaction between this polymorphism and calcium intake may account for the equivocal results. The goal of this study was to investigate the cross-sectional associations and dietary interaction between IL6-174C>G polymorphism and BMD at hip, spine and total body in 402 healthy older men and postmenopausal women (166 men and 236 women, mean age+/-SD, 68+/-5y). There was significant interaction between this polymorphism and dietary calcium intake in the prediction of BMD. In subjects with dietary calcium intake < 600 mg/day, minor allele carriers (GG+GC, n=51) had lower BMD compared with CC homozygotes (n=41), with a mean difference of 6% in total body BMD (p<0.001), 10.1% at the spine (p=0.003), 6.5% at femoral neck (p=0.0276) and 8.2% at trochanter (p=0.0034). In contrast, there was no significant association between this polymorphism and BMD in subjects with calcium intake of 600mg/day. In conclusion, IL6-174C>G is associated with lower BMD in older men and women with low calcium intake.