|Kehrli Jr, Marcus|
Submitted to: Journal of Dairy Science
Publication Type: Abstract Only
Publication Acceptance Date: 2/25/2006
Publication Date: 7/11/2006
Citation: Burvenich, C., Kehrli Jr, M.E., Paape, M.J., Bannerman, D.D., Lippolis, J.D. 2006. Cumulative physiological events influence the inflammatory response of the bovine udder to e-coli infections during the transition period. Journal of Dairy Science. 84(Suppl. 1):273. Interpretive Summary:
Technical Abstract: A high proportion of intramammary coliform infections present at parturition, may develop disease characterized by severe inflammatory signs and sepsis during the first 60-70 days of lactation. In the lactating bovine mammary gland innate immunity is the most important defense system. Since the beginning of the 90s, research on bovine mammary innate defense mechanisms in connection with the pathogenesis of coliform mastitis, increased significantly. There is no doubt that the viable neutrophil in the cisterns and ducts is a key factor in the protection of the mammary gland. However, in the bovine udder the protective role by the neutrophil seems to be influenced by a cumulation of physiological events occurring during the transition period. During the last 30 years most efforts have been focused on diapedesis, phagocytosis and killing by neutrophils, one of the most important components of the efferent innate arm. How these functions modulate the clinical outcome of coliform mastitis and how they can be influenced by hormones and metabolism have also been the subject of intensive research. The study of the afferent (sensing) arm of innate immunity that recognizes a diverse array of pathogens is a new area of interest and may also contribute to the variation in inflammatory responses.