|SHIN, SEUNG YOUNG|
|CHOI, UNG KYU|
|KIM, HAK RYUL|
|KANG, SUN CHUL|
Submitted to: Korean Journal of Agricultural Chemistry and Biotechnology
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 12/2/2005
Publication Date: 12/15/2005
Citation: Shin, S., Bajpai, V.K., Hou, C.T., Choi, U., Kim, H., Kang, S. 2005. Antibacterial activity of bioconverted linoleic acid produced by Pseudomonas aeruginosa PR3. Korean Journal of Agricultural Chemistry and Biotechnology. 48(4):167-169.
Interpretive Summary: We reported earlier that Pseudomonas aeruginosa PR3 isolated from water sample collected from pig farm near Morton, Illinois, produced many oxygenated fatty acids from oleic and linoleic acids. Hydroxy fatty acids are useful as starting materials for the synthesis of specialty chemicals, special military nylon, plastisizers, and coatings materials. Polyhydroxy unsaturated fatty acids are also valuable precursors for prostaglandin and other hormones synthesis, can act as fungicides in agricultural application, are precursors of flavor ingredients, and are chiral synthons of possible drug discovery interest. Now we found that crude extracts of bioconverted linoleic acid using P. aeruginosa PR3 showed antibacterial activity against several Gram (+) bacteria and one Gram (-) bacteria. Application of these new products either for bioactive agents or raw material for synthesis of specialty chemicals will benefit U.S. farmers.
Technical Abstract: Crude extract of bioconverted linoleic acid using Pseudomonas aeruginosa PR3 was evaluated for its antibacterial activity against food-borne pathogenic bacteria. Crude extract showed antibacterial activity against four Gram-positive bacteria, Staphylococcus aureus (ATCC 6538), S. aureus (KCTC 1916), Listeria monocytogenes (ATCC 19166), and Bacillus subtilis (ATCC 6633), and one Gram-negative bacterium, Pseudomonas aeruginosa (KCTC 2004), with minimum inhibitory concentrations ranging from 750 to 1,500 micro-grams ml-1. S. aureus and B. subtilis were selected for growth inhibition assays with bioconverted linoleic acid. Major antibacterial effects occurred at lag phase.