|Buckler, Edward - Ed|
Submitted to: Current Opinion in Biotechnology
Publication Type: Review Article
Publication Acceptance Date: 2/15/2006
Publication Date: 4/15/2006
Citation: Yu, J., Buckler Iv, E.S. 2006. Genetic association mapping and genome organization of maize. Current Opinion in Biotechnology. 17:155-160.
Technical Abstract: Association mapping, a high-resolution method for mapping QTL based on linkage disequilibrium, holds great promise for the dissection of complex genetic traits. Recent assembly and characterization of maize association mapping panels, development of improved statistical methods, and successful association of candidate genes with phenotypes have begun to realize the power of candidate-gene association mapping. Although the complexity of the maize genome poses several significant challenges to the application of association mapping, the proposed maize genome sequencing project will ultimately allow for a thorough genome-wide examination of nucleotide polymorphism-trait association. Here, we review these recent advances in maize association mapping and discuss maize genome structure and its implications for association mapping.