Submitted to: Springer Verlag
Publication Type: Book / Chapter
Publication Acceptance Date: 5/1/2006
Publication Date: 3/13/2007
Citation: Joseph, J.A., and Gibson, G.E. 2007. Coupling of neuronal function to oxygen and glucose metabolism through changes in neurotransmitter dynamics as revealed with aging, hypoglycemia and hypoxia. In Gibson, G.E. and Dienel, G., editors. Handbook of Neurochemistry and Molecular Biology. 3rd edition. Volume 5. New York, NY: Springer. p.297-320.
Technical Abstract: Normal brain function is tightly linked to adequate glucose and oxygen availability and to energy metabolism. This close coupling of metabolism to function is mediated, in part, through regulation of neurotransmitter dynamics. Metabolism may regulate neurotransmission by controlling synthesis, release or receptor interactions. Many of the effects of altered metabolism on neurotransmission are mediated by reactive oxygen species and calcium, and are modified by lipids. The coupling is difficult to demonstrate under normal conditions. However, the importance of the tight link between metabolism can be readily demonstrated with conditions that alter metabolism (e.g., hypoglycemia or hypoxia) or by normal aging. An understanding of these interactions will help our understanding of normal brain function as well as in the development of treatments for age-related neurodegenerative diseases.