ULTRASENSITIVE IMMUNOASSAYS BASED ON SURFACE-ENHANCED RAMAN SCATTERING BY IMMUNOGOLD LABELS

Authors: PARK, HYE-YOUNG - IOWA STATE UNIVERSITY; DRISKELL, JEREMY - IOWA STATE UNIVERSITY; KWARTA, KAREN - IOWA STATE UNIVERSITY; LIPERT, ROBERT - IOWA STATE UNIVERSITY; PORTER, MARC - IOWA STATE UNIVERSITY; SCHOEN, CHRISTIAN - CONCURRENT ANALYTICAL INC; Neill, John; Ridpath, Julia

Submitted to: Book Chapter
Publication Type: Book / Chapter
Publication Acceptance Date: 2/11/2006
Publication Date: 9/21/2006
Citation: Park, H., Driskell, J.D., Kwarta, K.M., Lipert, R.J., Porter, M.D., Schoen, C., Neill, J.D., Ridpath, J.F. 2006. Ultrasensitive Immunoassays Based on Surface-Enhanced Raman Scattering by Immunogold Labels. In: Kneipp, K., Moskovits., M., Kneipp, H., editors. Surface-Enhanced Raman Scattering - Physics and Applications, Topics in Applied Physics. Berlin/Heidelberg: Springer-Verlag. 103:427–446.

Interpretive Summary:

Technical Abstract: This chapter describes recent advances in the use of surface-enhanced Raman Scattering (SERS) as a readout tool for chip-scale, sandwich-based immunoassays. It reviews progress made in developing SERS-based immunoassays for a wide range of biolytes, including proteins, viruses and bacteria. The studies reviewed herein demonstrate that SERS-based immunoassay have the potential to serve as the cornerstone for a highly sensitive, high throughput bioanalytical methodology.