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ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Virus and Prion Research » Research » Publications at this Location » Publication #188663
Title: FLOW CYTOMETRY ANALYSIS OF WHITE TAILED DEER EXPOSED TO BVDV

Author
item MARK, C - SOUTH DAKOTA STATE UNIV
item Ridpath, Julia
item CHASE, C - SOUTH DAKOTA STATE UNIV

Submitted to: National Cattlemens Beef Association Annual Meeting
Publication Type: Abstract Only
Publication Acceptance Date: 1/30/2006
Publication Date: 1/30/2006
Citation: Mark, C.D., Ridpath, J.F., Chase, C.L. 2006. Flow cytometry analysis of white-tailed deer exposed to BVDV. BVD Symposium, National Cattlemen's Beef Association Annual Meeting. Paper No. P6. p. 48.

Interpretive Summary:

Technical Abstract: Two groups of four deer each, 2 to 4 weeks in age, were exposed to one of two bovine viral diarrhea virus (BVDV) strains: type 1b or type 2a, originally isolated from two different whitetail deer in southeast South Dakota in the fall of 2003. Two control age-matched deer were also used. Flow cytometry performed on whole blood collected on days -3, 3, 6, 9, 11, and 13 showed marked changes, indicating significant immunosuppressive effects classically observed in BVDV infection. Comparison of days -3 (baseline) and 3 days post infection (pi) showed the most significant effect with CD4+, CD8+, CD14+, CD18+, CD172+, and subpopulations of CD62L+ and MHC-II+ cells all decreasing by 15-80%. These data suggest that infection of deer with these deer isolate causes leukopenia in all cell subpopulations and BVDV may cause immunosuppression in deer.